PHOTOCHEMICAL COUPLING OF BENZO [a]PYRENE WITH 1-METHYL-CYTOSINE;PHOTO-ENHANCEMENT OF CARCINOGENICITY
Irradiation of the carcinogenic benzo[a]pyrene (I) with 1-methylcytosine hydrochloride IIa (molar ratio 1:10) at 3500 {angstrom} in methanol-acetone produces the 6-(1-methylcytos-5-yl)-benzo[a]pyrene (III). The structure of the product shows the hydrocarbon bound through the most active 6-carbon atom to the nucleophilic 5-position of the base. In the second part, the possibility of observing carcinogenic effects on the mouse skin from non-carcinogenic hydrocarbons under the action of UV light is investigated. Both experiments provide evidence that the 4,5-double bond (K region) of I presumably does not play a role in triggering the cancer process.
- Research Organization:
- Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
- Sponsoring Organization:
- USAEC
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 928500
- Report Number(s):
- UCRL--20246
- Country of Publication:
- United States
- Language:
- English
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