Functional heterogeneity among the T-derived lymphocytes of the mouse. III. Helper and suppressor T-cells activated by Concanavalin A. [Gamma Radiation, concanavalin A]
Journal Article
·
· Cell. Immunol.; (United States)
We have studied the properties of T-cells which when activated by concanavalin A (Con A) either suppress or help the in vitro humoral response of mouse spleen cells. Previously established criteria for the T-cell populations, T/sub 1/ and T/sub 2/ were applied. T/sub 1/ cells were defined by their short half-life (2-3 wk) after adult thymectomy (ATx) and their resistance to small doses of antithymocyte serum (ATS). T/sub 2/ cells were defined by their long half-life (approximately 15 wk) and their high sensitivity to ATS. T-cells which could be activated by Con A to help the response to the thymus-dependent antigen, sheep red blood cells, were found mainly in the T/sub 2/ subpopulation. T-cells which could be activated by Con A to suppress the response to the thymus-independent antigen, trinitrophenyl-lipopolysaccharide (TNP-LPS), were found within both the T/sub 1/ and T/sub 2/ subpopulations. These results, our previous results, and those of others suggest that the T-cell responses to phytomitogens distinguish precursors committed to different functions, while the T/sub 1/ and T/sub 2/ classifications distinguish T-cells at different stages of maturation.
- Research Organization:
- Univ. of Rochester School of Medicine and Dentistry, NY
- OSTI ID:
- 7362351
- Journal Information:
- Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 18:1; ISSN CLIMB
- Country of Publication:
- United States
- Language:
- English
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Immunoregulatory changes induced by total lymphoid irradiation. II. Development of thymus-leukemia antigen-positive and -negative suppressor T cells that differ in their regulatory function
Journal Article
·
Thu Jul 01 00:00:00 EDT 1976
· J. Immunol.; (United States)
·
OSTI ID:7187426
In vitro generation of helper T cells and suppressor T cells that regulate the cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells
Journal Article
·
Wed Mar 31 23:00:00 EST 1982
· Transplantation; (United States)
·
OSTI ID:6929189
Immunoregulatory changes induced by total lymphoid irradiation. II. Development of thymus-leukemia antigen-positive and -negative suppressor T cells that differ in their regulatory function
Journal Article
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Wed Jul 01 00:00:00 EDT 1981
· J. Exp. Med.; (United States)
·
OSTI ID:5576395
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IMMUNE REACTIONS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MEDICINE
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN
SURGERY
THYMECTOMY
THYMOCYTES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IMMUNE REACTIONS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MEDICINE
MICE
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SPLEEN
SURGERY
THYMECTOMY
THYMOCYTES
VERTEBRATES