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Studies on the immune response to fixed antigens. Preferential induction of helper function with heavily trinitrophenylated sheep erythrocytes, and glutaraldehyde-treated sheep erythrocytes

Journal Article · · J. Immunol.; (United States)
OSTI ID:7187426
; ; ;
Mice primed with heavily trinitrophenylated sheep red cells (TNP/sub 128/SRC) or glutaraldehyde-treated sheep red cells (G-SRC) developed an early helper function mediated by thymus-derived cells. Such mice were able to produce high secondary responses to both hapten and carrier after challenge 2 days after priming, with lightly trinitrophenylated SRC (TNP/sub 0/./sub 14/ SRC). However, the primary response of the TNP/sub 128/SRC or G-SRC-primed mice were very low to undetectable, and their secondary responses were also low when the challenge antigen was administered 4 days after priming or later. Inhibitory humoral factor(s) which were induced in the primed animals appeared responsible for the decreased capacity of primed mice to mount a secondary response when challenged later than 2 days after priming. Transfer of spleen cells from TNP/sub 128/SRC-primed mice to sublethally irradiated recipients circumvents their exposure to inhibitory humoral factor(s) present in intact animals allowing them to react with challenge antigen. Enriched populations of T cells, but not B cells, were able to transfer this early immunologic memory to irradiated recipients. The theoretical and practical implications of these results are discussed.
Research Organization:
Hebrew Univ., Jerusalem
OSTI ID:
7187426
Journal Information:
J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 117:1; ISSN JOIMA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL EXPLOSIVES
ERYTHROCYTES
EXPLOSIVES
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MICE
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHENOLS
PICRIC ACID
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
THYMOCYTES
VERTEBRATES