Opposite effects of total lymphoid irradiation on T cell-dependent and T cell-independent antibody responses
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:5071635
The effect of total lymphoid irradiation (TLI) on the primary antibody response to the dinitrophenylated heterologous protein, keyhole limpet hemocyanin (DNP-KLH), in complete Freund's adjuvant (CFA), and to the trinitrophenylated polysaccharide antigen, Brucella abortus (TNP-BA), was studied in BALB/c mice. The antibody response to both antigens was diminished in comparison with nonirradiated mice when antigens were injected within 3 days after TLI. When the mice were immunized 30 days after completion of TLI the antibody response to DNP-KLH in CFA was still diminished, but the antibody response to TNP-BA was enhanced 5- to 10-fold as compared with that of control animals. The opposite effect of TLI on the two antibody responses was also observed in a syngeneic primary adoptive transfer system.
- Research Organization:
- Stanford Univ. School of Medicine, CA
- OSTI ID:
- 5071635
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 132:2; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
Similar Records
T cell regulation of the thymus-independent antibody response to trinitrophenylated-Brucella abortus (TNP-BA)
Enhanced antibody affinity in sublethally irradiated mice and bone marrow chimeras
Total lymphoid irradiation reduces IgG autoantibody production and enhances specific antibody responses in NZB/NZW F1 mice
Journal Article
·
Sat Jun 01 00:00:00 EDT 1985
· J. Immunol.; (United States)
·
OSTI ID:5123433
Enhanced antibody affinity in sublethally irradiated mice and bone marrow chimeras
Journal Article
·
Mon Jan 31 23:00:00 EST 1977
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:7313355
Total lymphoid irradiation reduces IgG autoantibody production and enhances specific antibody responses in NZB/NZW F1 mice
Journal Article
·
Sat Jul 01 00:00:00 EDT 1989
· Cell. Immunol.; (United States)
·
OSTI ID:5596714
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODY FORMATION
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BRUCELLA
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IMMUNOLOGY
IMMUNOSUPPRESSION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MICROORGANISMS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
THYMUS CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODY FORMATION
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BRUCELLA
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IMMUNOLOGY
IMMUNOSUPPRESSION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MICROORGANISMS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
THYMUS CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION