Total lymphoid irradiation reduces IgG autoantibody production and enhances specific antibody responses in NZB/NZW F1 mice

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Cell. Immunol.; (United States)

DOI:https://doi.org/10.1016/0008-8749(89)90041-5· OSTI ID:5596714

Farinas, M C; Strober, S

Thymus-independent primary antibody responses were studied in young and old (9 months) untreated and TLI-treated NZB/NZW and BALB/c mice. Untreated old NZB/NZW mice had a low primary response to Brucella abortus (BA) as compared to that of young NZB/NZW and BALB/c mice. However, TLI treatment resulted in a 130-fold increase in the IgG anti-BA primary antibody response at day 21 postimmunization, achieving similar levels to those of young NZB/NZW or nonautoimmune BALB/c mice. Anti-TNP responses to trinitrophenylated BA or Ficoll were masked by high background levels of anti-TNP antibodies. Despite the increase in the anti-BA response, spontaneous immunoglobulin secretion and autoantibody levels were markedly decreased after TLI in old NZB/NZW mice.

• Research Organization: Stanford Univ. School of Medicine, CA (USA)
• OSTI ID: 5596714
• Journal Information: Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 121:2; ISSN CLIMB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
ANTIBODIES
ANTIBODY FORMATION
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
DISEASES
GLOBULINS
IMMUNE REACTIONS
IMMUNITY
IMMUNOGLOBULINS
INFECTIOUS DISEASES
LYMPHATIC SYSTEM
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SYNTHESIS
THYMUS
VERTEBRATES