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In vitro generation of helper T cells and suppressor T cells that regulate the cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells

Journal Article · · Transplantation; (United States)
; ; ; ;

Helper T cells and suppressor T cells have been generated in vitro that regulate the cytolytic T lymphocyte (CTL) response to trinitrophenyl (TNP)-modified syngeneic cells. B6D2F1 helper cells generated to TNP-modified parental (P1) cells augment the CTL response to those P1-TNP-modified antigens but not to P2-TNP-modified antigens. The generation of these helper T cells requires the presence of splenic adherent cells and these helper T cells are radioresistant. A soluble factor can be obtained from the helper T cell cultures that can also augment the CTL response. The suppressor T cells generated in culture do not demonstrate the specificity observed with the helper T cells; however, they are antigen-dependent in their induction. Whether helper or suppressor activity is obtained depends upon the length of time cells are cultured in vitro.

Research Organization:
Department of Pathology, Sidney Farber Cencer Institute, Boston, MA
OSTI ID:
6929189
Journal Information:
Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 33:4; ISSN TRPLA
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
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PHENOLS
PHYSIOLOGY
PICRIC ACID
RADIOSENSITIVITY
SOMATIC CELLS
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