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Tumorigenic action of beta, proton, electron and alpha radiation in rat skin. Comprehensive progress report, August 1, 1973--July 31, 1976. [UV radiation]

Technical Report ·
DOI:https://doi.org/10.2172/7356502· OSTI ID:7356502
;

Rat skin has been studied for a number of years as a model of radiation carcinogenesis in a solid tissue. Accessibility of the skin enables the tumors to be detected early so that growth rate, proliferation rate, and onset times can be established accurately and, of course, the superficial location permits an accurate assessment of doses and a localization of the radiation to the tissue of interest. We have been attempting to establish as accurately as possible the nature of the dose response curve, i.e., the rate of tumor occurrence as of function of radiation dose, and the importance of tumor induction of radiologic factors, such as dose rate, fractionation, dose localization, linear energy transfer and of biologic factors, such as the proliferative state of the hair follicles and epidermis at the time of and subsequent to irradiation. The interaction of radiation and other carcinogens, especially ultraviolet light, is under study because of epidemiologic evidence suggesting a potential synergism for induction of scalp tumors. Radiobiological recovery processes have been studied in tumor response experiments using split doses of radiation separated by various times. The recovery rate for electron induced tumors has been measured, and the oncogenic effects of high LET particles (proton, alpha, argon) are being investigated.

Research Organization:
New York Univ., N.Y. (USA). Inst. of Environmental Medicine
OSTI ID:
7356502
Report Number(s):
COO-3380-26
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA PARTICLES
ANIMALS
BARYONS
BETA PARTICLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
CARCINOGENESIS
CARCINOGENS
CHARGED PARTICLES
DISEASES
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
ENERGY TRANSFER
FERMIONS
FRACTIONATED IRRADIATION
HADRONS
IRRADIATION
LEPTONS
LET
MAMMALS
NEOPLASMS
NUCLEONS
ORGANS
PATHOGENESIS
PROTONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RECOVERY
RODENTS
SKIN
ULTRAVIOLET RADIATION
VERTEBRATES