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Tumorigenic action of beta, proton, electron and alpha radiation in rat skin. Progress report, August 1, 1975--July 31, 1976

Technical Report ·
DOI:https://doi.org/10.2172/7339132· OSTI ID:7339132
;
The carcinogenic effect of ionizing radiation on rat skin was studied in an attempt to learn more about radiation carcinogenesis, especially how various parameters of the irradiation, such as dose distribution within the tissue and dose rate, affect the yield of tumors. It was found that when the dose was localized to a small region of skin, the tumor yield was reduced and the magnitude of the reduction indicated that the region of reduced response might extend about 150 ..mu.. into the irradiated zone. The proliferative state of the hair follicles at the time of irradiation had relatively little effect on tumor induction although old animals are less susceptible than young or newborn animals. The penetration requirement of at least 0.3 mm for producing tumors suggests that the hair follicle germ cells could be the oncogenic targets. The recovery rate for tumor induction measured by split-dose exposure protocols was 4 hours for electrons. Proton radiation exhibited nearly complete recovery at 24 hours PI. UVL promotion of electron induced tumors did not significantly alter tumor yields. Radioresistance to tumor induction appears to increase with age.
Research Organization:
New York Univ., N.Y. (USA)
OSTI ID:
7339132
Report Number(s):
COO-3380-27
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALPHA SOURCES
ANIMAL CELLS
ANIMALS
BARYONS
BETA SOURCES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTRONS
ELEMENTARY PARTICLES
FERMIONS
HADRONS
HAIR FOLLICLES
ION SOURCES
LEPTONS
MAMMALS
NEOPLASMS
NUCLEONS
ORGANS
PARTICLE SOURCES
PATHOGENESIS
PROTONS
RADIATION EFFECTS
RADIATION SOURCES
RADIOINDUCTION
RADIOSENSITIVITY
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SKIN
VERTEBRATES