In vivo incorporation of /sup 14/C-leucine into brain protein of methylmercury treated rats
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
In an attempt to explain the sensitivity of the brain to methylmercury, investigators have monitored various biochemical parameters in systems poisoned with this compound. YOSHINO et al. (1966) measured changes in brain cortex slices from rats severely intoxicated with methylmercury. Although several alterations were observed in animals showing neurological symptoms, only protein synthesis decreased during both the latent period and after the onset of symptoms. It has recently been observed that in vivo brain protein synthesis tended to decrease in rats mildly intoxicated with methylmercury. No investigations have been reported concerning the effects of low or extremely high doses of methylmercury on in vivo protein synthesis. We, therefore, measured in vivo /sup 14/C-leucine incorporation into brain protein in 48 hour old rats which received low levels of the mercurial during the fetal stage, and also in severely poisoned adult female rats showing neurological symptoms.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 7354827
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 13:4; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOSYNTHESIS
BODY
BODY BURDEN
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
LABELLED COMPOUNDS
LEUCINE
MAMMALS
METHYLMERCURY
NEONATES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
PREGNANCY
PROTEINS
RATS
RODENTS
SYNTHESIS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOSYNTHESIS
BODY
BODY BURDEN
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
LABELLED COMPOUNDS
LEUCINE
MAMMALS
METHYLMERCURY
NEONATES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
PREGNANCY
PROTEINS
RATS
RODENTS
SYNTHESIS
TOXICITY
VERTEBRATES