Decreased uptake of GABA by dorsal ganglia in methylmercury-treated rats
Journal Article
·
· Neurotoxicology (Park Forest South, Ill.); (United States)
OSTI ID:5044962
The uptake of 14C-GABA and 14C-choline by cerebral cortex slices did not show any change in rats which showed neurological signs 7 days after the last 7 methylmercury injections (10 mg/kg/day). However, 14C-GABA uptake by dorsal ganglia greatly decreased, although 14C-choline uptake did not decrease in dorsal ganglia. 14C-GABA uptake by cerebellum also was somewhat decreased. The degree of inhibition of 14C-GABA uptake by dorsal ganglia increased each day after the commencement of methylmercury injection. The decrease of 3H-GABA uptake by dorsal ganglia of methylmercury-injected rats was confirmed by autoradiography. Autoradiographic and inhibitor studies showed labelled GABA accumulated in the satellite glial cells. In vitro addition of methylmercury (10(-4)-10(-5) M) equally inhibited the uptake of GABA and choline by brain and dorsal ganglia slices. These studies may reveal a possible mechanism of methylmercury neuropathy.
- Research Organization:
- Niigata Univ., Brain Research Inst., Japan
- OSTI ID:
- 5044962
- Journal Information:
- Neurotoxicology (Park Forest South, Ill.); (United States), Journal Name: Neurotoxicology (Park Forest South, Ill.); (United States) Vol. 2:3; ISSN NRTXD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBRUM
CHOLINE
DRUGS
GANGLIONS
HYDROXY COMPOUNDS
INHIBITION
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
MAMMALS
METABOLISM
METHYLMERCURY
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
QUATERNARY COMPOUNDS
RATS
RODENTS
UPTAKE
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBRUM
CHOLINE
DRUGS
GANGLIONS
HYDROXY COMPOUNDS
INHIBITION
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
MAMMALS
METABOLISM
METHYLMERCURY
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
QUATERNARY COMPOUNDS
RATS
RODENTS
UPTAKE
VERTEBRATES