Factors affecting the uptake of /sup 99m/Tc-sulfur colloid by the lung and kidney

Journal Article · Sun Aug 01 04:00:00 EDT 1976 · J. Nucl. Med.; (United States)

OSTI ID:7352941

Wagner, Jr, H N

Occasionally patients injected with /sup 99m/Tc-sulfur colloid (TSC) for liver-spleen imaging show increased uptake by the lungs or kidneys. In animals, increased lung uptake of TSC can be produced by injecting endotoxin intraperitoneally. Using an intraperitoneal endotoxin model, we studied the effect of heparin on dose-response curves for TSC uptake by the lungs and kidneys. Over a dose range of 1 ..mu..g to 10 mg of endotoxin, TSC uptake by the lungs increased progressively; heparin had no effect. In the kidneys, endotoxin in doses from 1 ..mu..g to 1 mg resulted in an increased TSC uptake which was less marked than that in the lungs and which was also unaffected by heparin. However, at a dose of 10 mg of endotoxin, a marked increase occurred in TSC uptake by the kidneys, and this could be prevented by heparin. Although the increased TSC uptake by the kidneys at lower doses of endotoxin and by the lungs at all doses is probably not related to intravascular coagulation, the marked increase in TSC uptake by the kidneys at 10 mg of intraperitoneal endotoxin probably is related to intravascular coagulation, possibly by entrapment in fibrin deposits in the renal capillaries.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore
• OSTI ID: 7352941
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 17:8; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
ANTICOAGULANTS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
COLLOIDS
DISPERSIONS
DRUGS
ENDOTOXINS
HEPARIN
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LUNGS
MAMMALS
MUCOPOLYSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
POLYSACCHARIDES
RADIOCOLLOIDS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPIRATORY SYSTEM
RODENTS
SACCHARIDES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOXIC MATERIALS
TOXINS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES