Absence of hepatic uptake of Tc-99m sulfur colloid in an infant with Coxsackie B2 viral infection
After the intravenous administration of Tc-99m sulfur colloid, there was found homogeneous lung, renal, and splenic uptake with absence of uptake by the liver and bone marrow of a nine-day-old female infant. More than 20 other doses were dispensed from the same Tc-99m sulfur colloid preparation with the expected biodistribution. A necropsy done two days later showed diffuse hepatic hemorrhagic necrosis without evidence of intravascular fibrin deposition in the lungs or kidneys. The underlying cause of the infant's disease was a Coxsackie B2 viral infection, based upon positive postmortem viral cultures of kidney and liver tissues and characteristic histopathologic lesions of the central nervous system and viscera. The altered biodistribution presumably reflected marked impairment of Kupffer cell function and an apparent increase in pulmonary macrophages.
- Research Organization:
- Ohio State University Hospitals, Columbus
- OSTI ID:
- 5745250
- Journal Information:
- Clin. Nucl. Med.; (United States), Vol. 8:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
TECHNETIUM 99
UPTAKE
VIRAL DISEASES
PATHOGENESIS
AUTOPSY
FEMALES
HEMORRHAGE
HEPATITIS
INFANTS
ISOMERIC NUCLEI
RADIOCOLLOIDS
RETICULOENDOTHELIAL SYSTEM
SULFUR
AGE GROUPS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHILDREN
COLLOIDS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM DISEASES
DISEASES
DISPERSIONS
ELEMENTS
HOURS LIVING RADIOISOTOPES
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPES
SYMPTOMS
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics