Effect of carbon monoxide on coronary heart disease

Journal Article · Tue Oct 01 04:00:00 EDT 1974 · Geriatrics; (United States)

OSTI ID:7347482

Aronow, W S

The effects of carbon monoxide on coronary heart disease are illustrated in a review of several studies involving the exposure of animals and humans to various concentrations of the gas. An association is cited between atmospheric carbon monoxide pollution in Los Angeles and mortality rates in patients with acute myocardial infarction admitted to 35 Los Angeles hospitals. Experiments with monkeys suffering from induced myocardial infarction show a greater degree of myocardial ischemia occurring in those exposed to 100 ppm CO than in those breathing room air. Patients with exercise-induced angina pectoris and exposed to heavy freeway traffic demonstrate mean arterial carboxyhemoglobin level increases from 1.12 to 5.08 percent after 90 min of driving; exercise time until the onset of angina pectoris is significantly shorter than during control periods. Ischemic S-T segment depressions of at least 1 mm greater amplitude than in control Holter electrocardiographic tracings are also observed in CO-exposed angina patients. Experiments are also cited linking carbon monoxide to the pathogenesis of coronary atherosclerosis and demonstrating the effect of smoking on carboxyhemoglobin levels.

• OSTI ID: 7347482
• Journal Information: Geriatrics; (United States), Journal Name: Geriatrics; (United States) Vol. 29:10; ISSN GERIA
• Country of Publication: United States
• Language: English

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AEROSOLS
AIR POLLUTION
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CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CARDIOVASCULAR DISEASES
CHALCOGENIDES
COLLOIDS
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MAMMALS
MONKEYS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PATIENTS
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PRIMATES
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SMOKES
SOLS
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VERTEBRATES