Effects of carbon monoxide on myocardial ischemia

Journal Article · Fri Feb 01 04:00:00 EST 1991 · Environmental Health Perspectives; (United States)

DOI:https://doi.org/10.1289/ehp.919189· OSTI ID:5010483

Allred, E N; Pagano, M ^[1]; Bleecker, E R; Walden, S M ^[2]; Chaitman, B R; Dahms, T E ^[3]; Hackney, J D; Selvester, R H ^[4]; Warren, J ^[5]; Gottlieb, S O

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1. Harvard Univ. School of Public Health, Boston, MA (United States)
2. John Hopkins Univ. School of Medicine, Baltimore, MD (United States)
3. St. Louis Univ. School of Medicine, MO (United States)
4. Rancho Los Amigos Medical Center, Downey, CA (United States)
5. Health Effects Inst., Cambridge, MA (United States)

The purpose of this study was to determine whether low doses of carbon monoxide (CO) exacerbate myocardial ischemia during a progressive exercise test. The effect of CO exposure was evaluated using the objective measure of time to development of electrocardiographic changes indicative of ischemia and the subjective measure of time to onset of angina. Sixty-three male subjects (41-75 years) with well-documented coronary artery disease, who had exertional angina pectoris and ischemic ST-segment changes in their electrocardiograms, were studied. Results from three randomized, double-blind test visits (room air, low and high CO) were compared. The effect of CO exposure was determined from the percent difference in the end points obtained on exercise tests performed before and after a 1-hr exposure to room air or CO. A significant dose-response relationship was found for the individual differences in the time to ST end point and angina for the pre-versus postexposure exercise test at the three carboxyhemoglobin levels. These findings demonstrate that low doses of CO produce significant effects on cardiac function during exercise in subjects with coronary artery disease.

• OSTI ID: 5010483
• Journal Information: Environmental Health Perspectives; (United States), Journal Name: Environmental Health Perspectives; (United States) Vol. 91; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

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560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AGE DEPENDENCE
ANEMIAS
ANIMALS
ARTERIES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CHEMISTRY
COLLOIDS
CORONARIES
DEMOGRAPHY
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
EXERCISE
HEART
HEMIC DISEASES
ISCHEMIA
MALES
MAMMALS
MAN
MEN
MUSCLES
MYOCARDIUM
ORGANS
OXIDES
OXYGEN COMPOUNDS
PRIMATES
RESIDUES
SMOKES
SOLS
SYMPTOMS
TOBACCO SMOKES
VASCULAR DISEASES
VERTEBRATES