Evaluation of myocardial uptake of /sup 99m/Tc pyrophosphate in clinical exercise-induced ventricular ischemia

Journal Article · Tue Mar 01 04:00:00 EST 1977 · Chest (Chicago); (United States)

OSTI ID:7083280

Berman, D S; Salel, A F; DeNardo, G L; Mason, D T

Although acute infarction of the myocardium is known to accumulate /sup 99m/Tc pyrophosphate, it is not entirely clear that ischemia alone without necrosis does not result in abnormal uptake of /sup 99m/Tc pyrophosphate. The present study investigates whether transient myocardial ischemia is associated with localization of /sup 99m/Tc pyrophospte by evaluating images obtained with the scintillation camera at rest and after exercise in 15 patients with unequivocal myocardial ischemia. All patients had angina pectoris, multivessel coronary artery stenoses by selective arteriographic studies, and electrocardiographic ischemic responses on treadmill exercise. Eleven of the 15 patients also underwent radionuclide imaging with /sup 81/Rb at rest and after exercise; the results demonstrated scintigraphic ischemia. The scintiscans with /sup 99m/Tc pyrophosphate revealed no evidence of increased myocardial radioactivity after exercise compared to rest in 14 of the 15 patients. In contrast, myocardial activity was observed with /sup 99m/Tc pyrophosphate after treadmill exertion in the remaining patient, in whom a small subendocardial infarction appeared to have occurred with the exercise. It is concluded from these results that transient myocardial ischemia does not cause localization of /sup 99m/Tc pyrophosphate. These findings support the specificity of abnormal localization of /sup 99m/Tc pyrophosphate for acute myocardial infarction.

• Research Organization: Univ. of California, Davis
• OSTI ID: 7083280
• Journal Information: Chest (Chicago); (United States), Journal Name: Chest (Chicago); (United States) Vol. 71:3; ISSN CHETB
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EXERCISE
HEART
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PATIENTS
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES