Effects of cadmium on karyotype stability in Chinese hamster ovary cells. Progress report, January 1--June 30, 1976

Technical Report · Sun Aug 01 04:00:00 EDT 1976

DOI:https://doi.org/10.2172/7339232· OSTI ID:7339232

Deaven, L L; Campbell, E W

Cadmium chloride solutions were added to cultures of hamster ovary cells in various concentrations and cells were examined for chromosomal aberrations at intervals. At a concentration of 2 x 10/sup -6/ M, cells showed no damage up to 24 h; at 48 h about 40 percent of cells showed chromatid damage; at 72 h 80 percent of metaphase cells had shattered chromosomes; after 1 week an increased number of tetraploid cells appeared. All concentrations had an inhibitory effect on mitosis. (HLW)

• Research Organization: Los Alamos Scientific Lab., N.Mex. (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 7339232
• Report Number(s): LA-6451-PR
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CELL DIVISION
CHLORIDES
CHLORINE COMPOUNDS
CHROMOSOMAL ABERRATIONS
DISPERSIONS
HALIDES
HALOGEN COMPOUNDS
HAMSTERS
INHIBITION
KARYOTYPE
MAMMALS
MITOSIS
MIXTURES
MUTATIONS
PLOIDY
RODENTS
SOLUTIONS
STABILITY
VERTEBRATES