Effect of cadmium chloride on cell division and chromosomes in Chinese hamster ovary cells

Journal Article · Sat Mar 01 04:00:00 EST 1986 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01623518· OSTI ID:5524548

Lakkad, B C; Nigam, S K; Karnik, A B; Thakore, K N; Chatterjee, B B

Effect of cadmium chloride on cell division and chromosomes was studied in Chinese Hamster Ovary (CHO) cells in vitro. The cell cultures were exposed to various concentrations of cadmium chloride. Different treatment of cadmium chloride resulted in various cell division abnormalities like micronucleus formation, lagging chromosome, and chromatid bridges. At higher doses, an abundance of pyknotic nuclei in the monolayer was noteworthy. The 24 hours continuous treatment caused chromosomal aberrations like chromatid gaps, breaks, exchanges and chromatid separation.

• Research Organization: National Institute of Occupational Health, Ahmedabad, India
• OSTI ID: 5524548
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 36:3; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CELL DIVISION
CHLORIDES
CHLORINE COMPOUNDS
CHO CELLS
CHROMOSOMES
HALIDES
HALOGEN COMPOUNDS
MITOSIS