Altered lymphocyte functions in rats bearing syngeneic moloney sarcoma tumors. II. Suppressor cells

Journal Article · Sun Aug 01 04:00:00 EDT 1976 · J. Immunol.; (United States)

OSTI ID:7339193

Veit, B C; Feldman, J D

Spleens from tumor-bearing rats contained a population of adherent cells that suppressed lymphocyte responses to Con A and LPS and cell-mediated cytotoxicity (CMC). By use of various fractionation procedures, Ig+ cells, T cells, and null cells were excluded as candidates for the suppressor cell activity. Procedures that removed macrophages abolished the suppressive activity whereas those procedures that enriched for or involved direct addition of macrophages resulted in augmented suppression. On the basis of these results, we conclude that the suppressor elements in spleens of tumor-bearing rats were macrophages.

• Research Organization: Scripps Clinic and Research Foundation, La Jolla, CA
• OSTI ID: 7339193
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 117:2; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
IMMUNE REACTIONS
LEUKOCYTES
LYMPHOCYTES
MACROPHAGES
MAMMALS
NEOPLASMS
ORGANS
PHAGOCYTES
RATS
RODENTS
SARCOMAS
SOMATIC CELLS
SPLEEN
SPLEEN CELLS
VERTEBRATES