Altered lymphocyte functions in rats bearing syngeneic moloney sarcoma tumors. I. Mitogen responses, mixed lymphocyte reactions (MLR) and mixed lymphocyte-tumor reactions (MLTR)

Journal Article · Sun Aug 01 04:00:00 EDT 1976 · J. Immunol.; (United States)

OSTI ID:7339197

Veit, B C; Feldman, J D

Impairment of mitogen responses to Con A and LPS and of MLR and MLTR was detected in the spleens of rats bearing syngeneic Moloney sarcoma tumors. Depressed responses of both T cell and Ig+ cell populations were observed. During the observation period of 6 to 10 days post-tumor inoculation when maximal T cell-mediated cytotoxicity was observed in spleen and draining lymph node cells, spleen cells showed marked impairment in response to stimuli mentioned above. By contrast, draining lymph node cell activity was either unaltered or somewhat elevated above the level of activity measured in normal control populations. Data presented in this and an accompanying paper strongly indicate that macrophages are activated as immunosuppressor cells in tumor-bearing rats.

• Research Organization: Scripps Clinic and Research Foundation, La Jolla, CA
• OSTI ID: 7339197
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 117:2; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
IMMUNE REACTIONS
LEUKOCYTES
LYMPHOCYTES
MACROPHAGES
MAMMALS
NEOPLASMS
PHAGOCYTES
RATS
RODENTS
SARCOMAS
SOMATIC CELLS
VERTEBRATES