Distribution of /sup 35/S-labeled WR-2721 in normal and malignant tissues of the mouse
Journal Article
·
· Radiat. Res.; (United States)
The radioprotective drug, WR-2721, labeled with /sup 35/S, has been evaluated for distribution in BALB/c mice bearing the EMT/sub 6/ mouse mammary tumor. At 6, 20, and 60 min after intravenous injection the animals were sacrificed and autoradiographs were made from sagittal sections taken through the entire animal. Radioactivity was high in bone marrow, intestinal mucosa, and skin, which correlates with the radioprotection produced by this drug in these organs. An initial high level in the kidney fell rapidly over the time period studied, suggesting rapid excretion of the drug by the kidneys. The EMT/sub 6/ tumor had a low concentration with only minimal increase over the 60-min period, which also correlates with the low level of radioprotection demonstrated in this tumor by WR-2721. Low levels were seen in muscle, lung, and peripheral blood while essentially no uptake occurred in the brain. The liver showed a persistent high level of radiolabeled drug uptake and the submandibular salivary gland contained the highest concentration of any organ of the body at 1 hr. This suggests the possibility of protection of these two normal structures, which could have great clinical significance in radiation therapy.
- Research Organization:
- Univ. of Kentucky, Lexington
- OSTI ID:
- 7338146
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 68:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE MARROW
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
EVEN-ODD NUCLEI
GLANDS
HEMATOPOIETIC SYSTEM
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LIGHT NUCLEI
LIVER
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
NUCLEI
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SALIVARY GLANDS
SKIN
SULFUR 35
SULFUR ISOTOPES
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE MARROW
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
EVEN-ODD NUCLEI
GLANDS
HEMATOPOIETIC SYSTEM
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LIGHT NUCLEI
LIVER
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
NUCLEI
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SALIVARY GLANDS
SKIN
SULFUR 35
SULFUR ISOTOPES
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
VERTEBRATES