Radioprotection of oral cavity structures by WR-2721. [Mice; dogs; x rays;. gamma. rays]

Journal Article · Sat Dec 31 23:00:00 EST 1977 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(78)90187-6· OSTI ID:6538728

Utley, J F ^[1]; King, R; Giansanti, J S

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1. Univ. of California

The finding of a high concentration of /sup 35/S--WR-2721 in mouse salivary glands led to studies of possible radioprotection of these glands from ionizing radiation. Oral effects of radiation in the presence of WR-2721 were studied in mice and dogs. The dose required to induce the oral radiation death syndrome (LD50/8-10) was increased by a factor of 2.1 in BALB/c mice when WR-2721 was given 30 minutes before irradiation of the head. Salivary flow in mongrel dogs following doses of 1000 to 3000 rad showed similar depression with and without the use of WR-2721. Therefore, the salivary gland may be an organ for metabolism or secretion of WR-2721 accounting for its high drug concentration. The skin and oral mucosa were protected by a factor of 1.7 (2500 rad with WR-2721 = 1500 rad without WR-2721) at moderate radiation reactions. This protection decreased to 1.2 at the level of radionecrosis (3000 rad with WR-2721 = 2500 rad without WR-2721). At clinically acceptable radiation reactions, WR-2721 offers the possibility of significant protection of normal epithelial structures of the head and neck.

• OSTI ID: 6538728
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 4:7-8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DOGS
DRUGS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ENERGY
EPILATION
ERYTHEMA
ESTERS
EXTERNAL IRRADIATION
GAMMA RADIATION
GLANDS
HEAT
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOCAL IRRADIATION
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUCOUS MEMBRANES
NECROSIS
NUCLEI
ODD-ODD NUCLEI
ORAL CAVITY
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PHOSPHORIC ACID ESTERS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SALIVARY GLANDS
SKIN
SPECIFICITY
SYMPTOMS
THIOLS
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES