Erythrocyte aminolevulinic acid dehydratase (ALAD) activity as a biologic parameter for determining exposures to lead
The response of the blood lead concentration and aminolevulinic acid dehydratase (ALAD) activity to lead exposure was studied in baboons. The results demonstrate that ALAD activity is depressed without there being a concomitant rapid increase in the blood lead concentration (PbB). Thus use of the ALAD test may indicate the occurrence of excessive lead exposure at an earlier time (24 to 48 hr) than is possible by the PbB measurement (blood lead concentrations exceeding 80 ..mu..g/100 ml only after 25 or 75 to 100 days, according to level and form of lead intake). The authors calculated an equation which at constant exposure conditions can be used to determine an ultimate (steady-state) value of PbB from an early ALAD activity measurement. From this study the authors conclude that depression of ALAD activity is the most sensitive measure available for determination of lead exposure.
- OSTI ID:
- 7337528
- Journal Information:
- J. Occup. Med.; (United States), Vol. 17:3
- Country of Publication:
- United States
- Language:
- English
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99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD
BIOLOGICAL ACCUMULATION
QUANTITATIVE CHEMICAL ANALYSIS
AMINOLEVULINIC ACID
APES
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BLOOD
DOSE-RESPONSE RELATIONSHIPS
ECOLOGICAL CONCENTRATION
ENZYMES
EQUATIONS
HEALTH HAZARDS
PUBLIC HEALTH
SAFETY STANDARDS
TOXICITY
AMINO ACIDS
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
ELEMENTS
HAZARDS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
STANDARDS
VERTEBRATES
500200* - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)
552000 - Public Health
550600 - Medicine
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)