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Erythrocyte aminolevulinic acid dehydratase (ALAD) activity as a biologic parameter for determining exposures to lead

Journal Article · · J. Occup. Med.; (United States)
OSTI ID:7337528
; ; ;
The response of the blood lead concentration and aminolevulinic acid dehydratase (ALAD) activity to lead exposure was studied in baboons. The results demonstrate that ALAD activity is depressed without there being a concomitant rapid increase in the blood lead concentration (PbB). Thus use of the ALAD test may indicate the occurrence of excessive lead exposure at an earlier time (24 to 48 hr) than is possible by the PbB measurement (blood lead concentrations exceeding 80 ..mu..g/100 ml only after 25 or 75 to 100 days, according to level and form of lead intake). The authors calculated an equation which at constant exposure conditions can be used to determine an ultimate (steady-state) value of PbB from an early ALAD activity measurement. From this study the authors conclude that depression of ALAD activity is the most sensitive measure available for determination of lead exposure.
OSTI ID:
7337528
Journal Information:
J. Occup. Med.; (United States), Journal Name: J. Occup. Med.; (United States) Vol. 17:3; ISSN JOCMA
Country of Publication:
United States
Language:
English

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500200* -- Environment
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54 ENVIRONMENTAL SCIENCES
550600 -- Medicine
552000 -- Public Health
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AMINO ACIDS
AMINOLEVULINIC ACID
ANIMALS
APES
BIOASSAY
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
DOSE-RESPONSE RELATIONSHIPS
ECOLOGICAL CONCENTRATION
ELEMENTS
ENZYMES
EQUATIONS
HAZARDS
HEALTH HAZARDS
LEAD
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
PUBLIC HEALTH
QUANTITATIVE CHEMICAL ANALYSIS
SAFETY STANDARDS
STANDARDS
TOXICITY
VERTEBRATES