Erythrocyte delta-aminolevulinic acid dehydratase activity as a measure of lead exposure
Journal Article
·
· J. Lab. Clin. Med.; (United States)
OSTI ID:5224882
The measurement of erythrocyte delta-aminolevulinic acid dehydratase (ALA-D) activity has been found to be a useful guide to lead exposure for screening purposes. The pH of the test should be well-controlled for adequate clinical interpretation. False-normal tests are rare even with iron-deficiency anemia or macrocytosis. Recent transfusion and recent bleeding or hemolysis with reticulocytosis tend to invalidate the test. ALA-D activity above 600 International Units effectively excludes significant lead exposure and eliminates the need for further testing. ALA-D activity is maximally depressed at a red cell lead concentration of 200 ..mu..g per 100 ml. When activity is moderately depressed, interpretation is difficult and the urinary excretion of lead after the administration of a chelating agent is usually required to differentiate the degree and significance of lead exposure. 41 references.
- Research Organization:
- Univ. of Alabama School of Medicine, Birmingham
- OSTI ID:
- 5224882
- Journal Information:
- J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 85:5; ISSN JLCMA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Journal Article
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Thu Aug 01 00:00:00 EDT 1974
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·
OSTI ID:7349132
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Conference
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Sat Dec 30 23:00:00 EST 1995
·
OSTI ID:244884
Erythrocyte aminolevulinic acid dehydratase (ALAD) activity as a biologic parameter for determining exposures to lead
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·
Sat Mar 01 00:00:00 EDT 1975
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·
OSTI ID:7337528
Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALABAMA
AMINO ACIDS
AMINOLEVULINIC ACID
ANEMIAS
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD CHEMISTRY
BODY FLUIDS
CARBON-OXYGEN LYASES
CARBOXYLIC ACIDS
DATA
DISEASES
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ERYTHROCYTES
EXPERIMENTAL DATA
FEDERAL REGION IV
HEMIC DISEASES
INFORMATION
LEAD
LYASES
MAMMALS
MAN
MATERIALS
METALS
NORTH AMERICA
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
PH VALUE
PRIMATES
SCREENING
SYMPTOMS
TOXICITY
USA
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALABAMA
AMINO ACIDS
AMINOLEVULINIC ACID
ANEMIAS
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD CHEMISTRY
BODY FLUIDS
CARBON-OXYGEN LYASES
CARBOXYLIC ACIDS
DATA
DISEASES
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ERYTHROCYTES
EXPERIMENTAL DATA
FEDERAL REGION IV
HEMIC DISEASES
INFORMATION
LEAD
LYASES
MAMMALS
MAN
MATERIALS
METALS
NORTH AMERICA
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
PH VALUE
PRIMATES
SCREENING
SYMPTOMS
TOXICITY
USA
VERTEBRATES