Iodine-125--digoxin radioimmunoassay: comparison of commercial kits

Journal Article · Wed Sep 01 04:00:00 EDT 1976 · J. Nucl. Med.; (United States)

OSTI ID:7337457

Battaglia, D J; Cianci, M L

Iodine-125-digoxin radioimmunoassay kits available from Abbott Diagnostics (AD), Dade Division (D), Schwarz/Mann (SM), and Clinical Assays (CA) were evaluated with respect to assay quality. The kit accuracies did not differ significantly at 2.0 ng/ml and the interassay coefficients of variation ranged from 9 percent (AD) to 21.4 percent (CA). The accuracy for all kits above 4 ng/ml is questionable, and since serum-dilution values correlated well with undiluted serum values, the dilution method of dose quantitation is preferable for levels above 4 ng/ml. Although all the kits were adequate for evaluating digoxin at the 2 ng/ml level, the Abbott kit seems to be of slightly better quality.

• Research Organization: Hunter Memorial Lab., Washington, DC
• OSTI ID: 7337457
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 17:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
BETA DECAY RADIOISOTOPES
CARBOHYDRATES
CARDIOTONICS
DAYS LIVING RADIOISOTOPES
DIGITALIS GLYCOSIDES
DIGOXIN
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLYCOSIDES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
STEROIDS
TRACER TECHNIQUES