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Lysosomal enzyme activation in irradiated mammary tumors. [X radiation, mice]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574340· OSTI ID:7333840
;
Lysosomal enzyme activity of C3H mouse mammary tumors was measured quantitatively by a histochemical method. Following whole-body doses of 3600 rad or less no changes were observed in the lysosomal enzyme activity for 12 hr after the irradiation, but very large increases in acid phosphatase and ..beta..-naphthylamidase activity were, however, observed 24 hr after irradiation. Significant increases in enzyme activity were detected 72 hr after a dose of 300 rad and the increases of enzyme activity were dose dependent over the range 300 to 900 rad. Testosterone (80 mg/kg) injected into mice 2 hr before irradiation (850 rad) caused a significant increase of lysosomal enzyme activity over and above that of the same dose of irradiation alone. If the tumor-bearing mice were given 95 percent oxygen/5 percent carbon dioxide to breathe for 8 min before irradiation the effect of 850 rad on lysosomal acid phosphatase was increased to 160 percent/that of the irradiation given alone. Activitation of lysosomal enzymes in mammary tumors is an important primary or secondary consequence of radiation.
Research Organization:
St. Bartholomew's Hospital, London
OSTI ID:
7333840
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID PHOSPHATASE
ANDROGENS
ANDROSTANES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CELL CONSTITUENTS
CHALCOGENIDES
CRYOGENIC FLUIDS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENZYMES
ESTERASES
FLUIDS
GLANDS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
IONIZING RADIATIONS
KETONES
LYSOSOMES
MAMMALS
MAMMARY GLANDS
METABOLISM
MICE
NEOPLASMS
NONMETALS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
PHOSPHATASES
RADIATION EFFECTS
RADIATIONS
RODENTS
STEROID HORMONES
STEROIDS
TESTOSTERONE
VERTEBRATES
X RADIATION