Quantifying the size of ischemic, infarcted and/or scarred myocardium-methods suitable for use in living man. identification of regional myocardial perfusion defects by radioisotope scintiscanning. Report for Jul 1971--Jun 1975
Technical Report
·
OSTI ID:7330266
The purpose of this project was to develop scintigraphic methods for quantification of regional myocardial ischemia and infarction. Labeled potassium analogs and fatty acids experimentally have been used as flow indicators but potassium-43, cesium-219 and carbon-11 labeled fatty acids did not prove satisfactory clinically because of suboptimal physical characteristics. However, terminally iodinated hexadecenoic acid, tagged with iodine-123, now is being evaluated as a potentially applicable radiopharmaceutical. Detection of an ischemic defect alone is not sufficient in infarct evaluations as the age is not defined. Fortuitously, a number of radioactive agents tend to localize around acutely damaged myocardial tissue and produce 'positive' images. Of particular interest is a group of technetium-99m phosphate compounds. Although the information provided is not quantitative, this method, combined with the regional perfusion techniques, can be used to distinguish acute myocardial ischemia and injury from other causes of ischemia. (GRA)
- OSTI ID:
- 7330266
- Report Number(s):
- PB-245838
- Country of Publication:
- United States
- Language:
- English
Similar Records
Myocardial imaging with /sup 123/I-hexadecenoic acid
Relation between regional distribution of /sup 201/Tl and myocardial blood flow in normal, acutely ischemic, and infarcted myocardium
Experimental basis for myocardial imaging with /sup 123/I-labeled hexadecnoic acid. [/sup 11/C, /sup 43/K]
Journal Article
·
Mon Aug 01 00:00:00 EDT 1977
· Radiology; (United States)
·
OSTI ID:7294572
Relation between regional distribution of /sup 201/Tl and myocardial blood flow in normal, acutely ischemic, and infarcted myocardium
Journal Article
·
Sun Oct 31 23:00:00 EST 1982
· Am. J. Cardiol.; (United States)
·
OSTI ID:6622607
Experimental basis for myocardial imaging with /sup 123/I-labeled hexadecnoic acid. [/sup 11/C, /sup 43/K]
Journal Article
·
Tue Nov 30 23:00:00 EST 1976
· J. Nucl. Med.; (United States)
·
OSTI ID:7236791
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES