Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Experimental basis for myocardial imaging with /sup 123/I-labeled hexadecnoic acid. [/sup 11/C, /sup 43/K]

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:7236791
; ; ;

Progress in myocardial perfusion imaging has been slowed by the lack of radiopharmaceuticals with suitable physical and biologic characteristics. Hexadecanoic acid, terminally labeled with /sup 123/I, partially overcomes these limitations by providing a compound that concentrates in the myocardium in proportion to relative regional blood flow and carries a gamma-emitter with desirable detection and imaging qualities. After intravenous injection in experimental animals, the clearance half-times of hexadecanoic acid for blood and myocardium are 1.7 and 20 min, respectively. These values compare favorably with 18-carbon fatty-acid analogs labeled with /sup 11/C. In acute and chronic infarction, similar distribution patterns are found for hexadecenoic acid and /sup 43/K, which indicates that hexadecenoic acid is a suitable substitute for the potassium analogs now in use for myocardial imaging. Because of the high count rates obtainable with /sup 123/I-hexadecanoic acid, good-quality images can be acquired in as little as 2--3 min per view. Iodine-123-hexadecanoic acid is potentially a useful radiopharmaceutical for clinical application.

Research Organization:
Univ. of California, Los Angeles
OSTI ID:
7236791
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 17:12; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

Myocardial imaging with /sup 123/I-hexadecenoic acid
Journal Article · Mon Aug 01 00:00:00 EDT 1977 · Radiology; (United States) · OSTI ID:7294572
Myocardial imaging and metabolic studies with (17-/sup 123/I)iodoheptadecanoic acid
Conference · Fri Oct 31 23:00:00 EST 1980 · J. Nucl. Med.; (United States) · OSTI ID:6819557
Myocardial uptake of labeled oleic and linoleic acids
Journal Article · Mon Sep 01 00:00:00 EDT 1975 · J. Nucl. Med., v. 16, no. 9, pp. 842-845 · OSTI ID:4162114

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
HEXADECANOIC ACID
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POTASSIUM 43
POTASSIUM ISOTOPES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING