Characterization of antibodies to the structural polypeptides of HB/sub s/Ag: evidence for subtype-specific determinants

Journal Article · Fri Oct 01 04:00:00 EDT 1976 · J. Immunol.; (United States)

OSTI ID:7326437

Gold, J W.M. ^[1]; Shih, J W.K.; Purcell, R H; Gerin, J L

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1. Oak Ridge National Lab., Rockville, MD

Antisera prepared in guinea pigs to the structural polypeptides of HB/sub s/Ag/adw and HB/sub s/Ag/ayw were examined by a modified passive hemagglutination assay for antibodies to the subtype-specific d and y determinants. All of the isolated polypeptide fractions stimulated antibodies to both group-specific and subtype-specific antigens of the native HB/sub s/Ag particle from which they were derived. These data indicate that the polypeptides have similarities in their immunochemical structure.

• OSTI ID: 7326437
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 117:4; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AGGLUTININS
ANIMALS
ANTIBODIES
CHEMICAL PROPERTIES
GUINEA PIGS
HEMAGGLUTININS
IMMUNE SERUMS
MAMMALS
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RODENTS
VERTEBRATES