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Induction of generalized Shwartzman reaction (GSR) in irradiated rabbits by a single injection of endotoxin

Journal Article · · Thromb. Res.; (United States)
Rabbits were prepared to GSR by either a single dose 30 ..mu..g/kg of Salmonella enteritidis endotoxin or by a single whole-body exposure to 850 R of x ray. After 24 hrs provocative dose of endotoxin 50 ..mu..g/kg was injected. Histological examinations of kidneys revealed that GSR occurred with equal frequency in both groups of rabbits but was more severe in the animals prepared by irradiation. Protamine gelation test detected soluble fibrin complexes in plasma in about 50% of rabbits 24 hrs after either of the preparatory procedures and virtually in 100% after the provocative endotoxin dose. During the preparatory phase of GSR the irradiation induced a profound decrease in blood lymphocyte count and in the weight of thymus and spleen. It is postulated that early postexposure lysis of lymphatic cells participates in mechanisms leading to thrombotic phenomena after irradiation.
Research Organization:
Inst. of Nuclear Research, Warsaw
OSTI ID:
7323806
Journal Information:
Thromb. Res.; (United States), Journal Name: Thromb. Res.; (United States) Vol. 8:4; ISSN THBRA
Country of Publication:
United States
Language:
English