Bursa of fabricius: uptake of radioactive particles and radiotoxic sealing of bursal follicles

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Adv. Exp. Med. Biol.; (United States)

DOI:https://doi.org/10.1007/978-1-4613-4355-4_5· OSTI ID:7322805

Schaffner, T ^[1]; Herring, J; Gerber, H; Cottier, H

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1. Univ., Bern

Making use of the fact that the avian bursa is uniquely equiped for uptake, degradation and storage of particulate matter from the cloacal lumen, we administered /sup 239/Pu(IV) perorally or via the cloaca to cause radiotoxic damage to the bursal tissue. This resulted in an involution of the follicles, reduction of the lymphocyte mass, predominance of small lymphoid cells in the medulla as compared to controls, disappearance of tuft epithelia, formation of a subepithelial fibrous layer in many follicles and impairment or an almost complete loss of the capacity of the bursa to take up particulate matter. Concomitant with these changes was a reduction in the concentration of serum IgG. These findings are discussed in relation to the immunologic contact role of the bursa.

• OSTI ID: 7322805
• Journal Information: Adv. Exp. Med. Biol.; (United States), Journal Name: Adv. Exp. Med. Biol.; (United States) Vol. 66; ISSN AEMBA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIRDS
EVEN-ODD NUCLEI
GLOBULINS
HEAVY NUCLEI
IMMUNITY
IMMUNOGLOBULINS
ISOTOPES
LYMPHATIC SYSTEM
NUCLEI
ORGANIC COMPOUNDS
PLUTONIUM 239
PLUTONIUM ISOTOPES
PROTEINS
RADIATION EFFECTS
RADIOISOTOPES
RADIOTOXINS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES