Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Fate of intraintestinal thymocytes labeled with /sup 125/iododeoxyuridine or tritiated thymidine. [Mice]

Journal Article · · Proc. Soc. Exp. Biol. Med.; (United States)
A suspension of thymocytes labeled with /sup 125/IUdR or /sup 3/HTdR was injected into the jejunum of mice. The bulk of the radioactivity disappeared within few hours from the intestine and was recovered principally in the urine. This indicated a very rapid breakdown of labeled thymic cells, reabsorption and subsequent elimination of the tracer in the kidney. In mice injected with cells labeled with /sup 3/HTdR, the initial rapid loss of radioactivity was of shorter duration, and slower during the second phase, presumably due to more extensive reutilization and/or prolonged persistence of acid-soluble radioactivity. Pretreatment of the recipients with antibiotics did not significantly reduce the rate of radioactivity loss.
Research Organization:
Brookhaven National Lab., Upton, NY
OSTI ID:
7316459
Journal Information:
Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 152; ISSN PSEBA
Country of Publication:
United States
Language:
English

Similar Records

Fate of thymic radioactivity after local labeling with $sup 125$Iododeoxyuridine
Journal Article · Wed Dec 31 23:00:00 EST 1975 · Blood, v. 47, no. 1, pp. 21-30 · OSTI ID:4086352

Double labeling with (/sup 3/H)thymidine and (/sup 125/I)iododeoxyuridine as a method for determining the fate of injected DNA and cells in vivo. [Mice]
Journal Article · Tue Dec 31 23:00:00 EST 1974 · J. Cell Biol.; (United States) · OSTI ID:7279297

Uptake of /sup 125/I-iododeoxyuridine in mouse organs during deuteration of body water: evidence for a thymus-specific effect
Journal Article · Wed Dec 31 23:00:00 EST 1975 · Life Sci.; (United States) · OSTI ID:7331990