Uptake of /sup 125/I-iododeoxyuridine in mouse organs during deuteration of body water: evidence for a thymus-specific effect

Journal Article · Thu Jan 01 04:00:00 UTC 1976 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(76)90160-0· OSTI ID:7331990

Laissue, J A; Slatkin, D N

The effects of body water deuteration on mammalian DNA synthesis in vivo during the deuterium equilibration period in the body were studied. Young adult mice were given 15 percent or 30 percent D/sub 2/O in the drinking water for 4, 10 or 21 days. Control mice were given distilled water. Eighteen hours prior to sacrifice, /sup 125/IUdR, a conveniently monitored synthetic analogue of the DNA precursor thymidine, was injected intravenously. Although neither radioiodine activity of the total body nor body weight varied significantly among the three groups, thymic radioactivity per g tissue was significantly lower in mice given 30 percent D/sub 2/O and, to a lesser extent, in mice given 15 percent D/sub 2/O than in the control group. In contrast, intestine and hemopoietic bone marrow displayed minor changes in /sup 125/IUdR incorporation. This reduction of /sup 125/IUdR incorporation is discussed in relation to the particular importance of thymidine reutilization in the thymus.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 7331990
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 19; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DEUTERIUM
DNA
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
IODODEOXYURIDINE
IODOURACILS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LYMPHATIC SYSTEM
MAMMALS
MICE
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
RODENTS
STABLE ISOTOPES
SYNTHESIS
THYMUS
TRACER TECHNIQUES
URACILS
VERTEBRATES