Superoxide dismutase and pulmonary ozone toxicity

Journal Article · Thu Mar 31 23:00:00 EST 1977 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(77)90491-X· OSTI ID:7316453

Douglas, J S; Curry, G; Geffkin, S A

Rats and mice were pre-exposed to low concentrations of ozone and subsequently challenged with higher concentrations of this gas. When the mortalities of pre-exposed and control animals were compared after a lethal challenge, there was a significant difference in ozone toxicity. The levels of superoxide dismutase in lung tissue of control and ozone tolerant rats or mice were not significantly different whether the results were expressed as units of activity per mg protein of lung tissue or as total units of enzyme activity per lung. Mice which were tolerant to ozone were not tolerant to oxygen. The data suggest that ozone tolerance is unrelated to an induction of superoxide dismutase. It is suggested that the induction of tolerance to oxygen and ozone involve biochemically distinct mechanisms.

• Research Organization: Yale Univ., New Haven
• OSTI ID: 7316453
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 20:7; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL ADAPTATION
BODY
CHALCOGENIDES
CHEMISTRY
CRYOGENIC FLUIDS
DATA
ELEMENTS
ENZYMES
FLUIDS
INFORMATION
LUNGS
MAMMALS
MICE
MORTALITY
NONMETALS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
OZONE
PROTEINS
QUANTITY RATIO
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUES
TOXICITY
VERTEBRATES