Reference sample method for cardiac output and regional blood flow determinations in the rat

Journal Article · Mon Mar 01 04:00:00 EST 1976 · J. Appl. Physiol.; (United States)

OSTI ID:7313421

Malik, A B; Kaplan, J E; Saba, T M

The reference sample method was used for simultaneous determinations of cardiac output and regional blood flows in conscious rats. Microspheres (15 +- 5 ..mu..m in diam) labeled with /sup 85/Sr were injected into the left ventricle and known volumes of reference sample were withdrawn from peripheral arteries. The calculated cardiac output measurements agreed with the previously reported values in rats. The percent distribution of the cardiac output to the brain, intestinal bed, and lungs were different from the reported values obtained in the rats using larger spheres. These differences may be related to the use of smaller spheres and to differences in the preparation. The absolute regional flows to various organs expressed in terms of milliliters per minute per gram tissue weight were also determined. The results indicate that the reference sample method can be applied to smaller mammals for determinations of regional flows and cardiac output.

• OSTI ID: 7313421
• Journal Information: J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 40:3; ISSN JAPYA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEASURING METHODS
MICROSPHERES
NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
STRONTIUM 85
STRONTIUM ISOTOPES
VERTEBRATES