Cardiac output and regional blood flow following trauma

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Circ. Shock; (United States)

OSTI ID:5062744

Malik, A B; Loegering, D J; Saba, T M; Kaplan, J E

The changes in cardiac output (2), regional blood blow (2r) and regional vascular resistance, and arterial pressure were studied in rats subjected to moderate (LD0) or severe (LD50) traumatic shock. 2 and 2r were determined using microspheres at 15, 60 and 180 min posttrauma. Arterial pressure decreased in both groups at 15 min and recovered by 3 h after sublethal (LD0) trauma, while arterial pressure did not return to control levels after LD50 trauma. 2 decreased in both groups at 15 min and returned to control only in the LD0 trauma group by 3 h. Cerebral, coronary, and hepatic arterial flows and resistances were maintained in both groups. Renal, intestinal, and splenic flows decreased and resistances were maintained in both groups. Renal, intestinal, and splenic flows decreased and resistances increased in both groups by 15 min and returned to control levels by 3 h only in the LD0 trauma group. Total hepatic and hepatic portal flows decreased at 60 min and returned to control levels at 3 h after LD0 trauma, while there was significant depression in these parameters 3 h after LD50 trauma. Therefore, sublethal and severe trauma resulted in early redistribution of flow favoring the coronary, cerebral, and hepatic arterial beds. However, renal, intestinal, splenic, and portal flows remained depressed only in severely traumatized rats, suggesting that continued hypofusion is a factor in the multiple organ failure and death following severe traumatic injury.

• Research Organization: Albany Medical Coll., NY
• OSTI ID: 5062744
• Journal Information: Circ. Shock; (United States), Journal Name: Circ. Shock; (United States) Vol. 5:1; ISSN CRSHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BIOLOGICAL SHOCK
BLOOD CIRCULATION
BLOOD PRESSURE
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRUM
CORONARIES
COUNTING TECHNIQUES
DEATH
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GLANDS
KIDNEYS
LIVER
MAMMALS
MICROSPHERES
NERVOUS SYSTEM
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SCINTISCANNING
SPLEEN
VERTEBRATES