Aminoaciduria and proteinuria in rats after a single intraperitoneal injection of Ni(II)

Journal Article · Wed Jan 01 00:00:00 EST 1975 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(75)90136-2· OSTI ID:7313318

Gitlitz, P H; Sunderman, Jr, F W; Goldblatt, P J

Proteinuria was found in Fischer female rats after a single ip injection of NiCl/sub 2/ in dosages from 34 to 85 ..mu..mol/kg (2 to 5 mg Ni/kg). Generalized ..cap alpha..-aminoaciduria was found after a single ip injection of NiCl/sub 2/ in dosages of 68 to 85 ..mu..mol/kg (4 and 5 mg Ni/kg). Amino acids in plasma were normal or slightly diminished from 1 to 48 hr after injection of Ni(II). Electron microscopy of kidneys of five rats at 48 hr after Ni(II) (68 ..mu..mol/kg) consistently revealed fusion of foot processes of glomerular epithelial cells. Focal tubular necrosis was present in the kidney of one of these rats. This study demonstrates that toxic nephropathy with aminoaciduria and proteinuria develops in rats after ip Ni(II). Amino acid and protein excretions consistently returned to normal by Day 5.

• Research Organization: Univ. of Connecticut, Farmington
• OSTI ID: 7313318
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Vol. 34
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
EXCRETION
KIDNEYS
NECROSIS
NICKEL CHLORIDES
TOXICITY
PROTEINS
BLOOD PLASMA
ELECTRON MICROSCOPY
RATS
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DISEASES
HALIDES
HALOGEN COMPOUNDS
MAMMALS
MICROSCOPY
NICKEL COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)