Increased lipid peroxidation in tissues of nickel chloride-treated rats

Conference · Mon Dec 31 23:00:00 EST 1984 · Ann. Clin. Lab. Sci.; (United States)

OSTI ID:5962963

Sunderman, Jr, F W; Marzouk, A; Hopfer, S M; Zaharia, O; Reid, M C

Parenteral administration of nickel chloride (NiCl/sub 2/) to rats enhanced lipid peroxidation in liver, kidney, and lung as measured by the thiobarbituric acid reaction for malondialdehyde (MDA) and related chromogens in fresh tissue homogenates. After sc injection of NiCl/sub 2/ (0.75 mmol per kg body wt), MDA concentrations in liver and kidney became significantly increased by nine h and reached peak values at 48 h. For example, in nine rats killed 48 h after the NiCl/sub 2/ injection, hepatic MDA concentrations averaged 2.5 +/- 1.0 ..mu.. mol per g dry wt (P < 0.001 versus 0.5 +/- 0.3 ..mu.. mol per g in 30 controls). Dose-effect relationships for lipid peroxidation in liver and kidney were observed with NiCl/sub 2/ dosages ranging from 0.12 to 0.75 mmol per kg, sc. Intrarenal administration of a carcinogenic nickel compound, nickel subsulfide (Ni/sub 3/S/sub 2/, 0.36 mmol per kg body wt), did not affect MDA concentrations in the injected kidneys of rats killed one to 20 days post-injection. The results of this study implicate lipid peroxidation as a molecular mechanism for cell injury in acute NiCl/sub 2/ poisoning, but they do not furnish any evidence that lipid peroxidation is involved in the initiation of nickel carcinogenesis. 46 references, 4 tables.

• Research Organization: Univ. of Connecticut School of Medicine, Farmington
• OSTI ID: 5962963
• Journal Information: Ann. Clin. Lab. Sci.; (United States), Journal Name: Ann. Clin. Lab. Sci.; (United States) Vol. 15:3; ISSN ACLSC
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
DATA
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
GLANDS
HALIDES
HALOGEN COMPOUNDS
INFORMATION
KIDNEYS
LIPIDS
LIVER
LUNGS
MAMMALS
METABOLISM
NICKEL CHLORIDES
NICKEL COMPOUNDS
NICKEL SULFIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
RATS
RESPIRATORY SYSTEM
RODENTS
SULFIDES
SULFUR COMPOUNDS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES