Effects of nickel chloride and nickel carbonyl upon glucose metabolism in rats

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Ann. Clin. Lab. Sci.; (United States)

OSTI ID:6791108

Horak, E; Zygowicz, E R; Tarabishy, R; Mitchell, J M; Sunderman, Jr, F W

Hyperglycemia, hyperglucagonemia and hyperinsulinemia were observed in fasting rats 0.5 h after ip injection of NiCl/sub 2/ (68 ..mu..mole per kg). Infusion of somatostatine iv (0.5 mg per rat) did not prevent Ni(II)-mediated hyperglycemia, hyperglucagonemia or hyperinsulinemia. Exposure of rats to inhalation of Ni(CO)/sub 4/ (1.2 to 6.4 ..mu..mole per liter of air per 15 min) caused acute hyperglycemia, similar to that observed after ip injection of NiCl/sub 2/. Hyperglycemia induced by NiCl/sub 2/ and Ni(CO)/sub 4/ was not associated with inhibition of erythrocyte glycolysis measured in vitro by erythrocyte uptake of 1-/sup 14/C-glucose and release of /sup 14/CO/sub 2/. These findings indicate that Ni-induced hyperglycemia may be mediated by increased pancreatic release of glucagon, but that Ni stimulation of glucagon release differs from stimulation of glucagon release by arginine or epinephrine, since the Ni effect is not antagonized by somatostatin.

• Research Organization: Univ. of Connecticut School of Medicine, Farmington
• OSTI ID: 6791108
• Journal Information: Ann. Clin. Lab. Sci.; (United States), Journal Name: Ann. Clin. Lab. Sci.; (United States) Vol. 8:6; ISSN ACLSC
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ADRENALINE
ALDEHYDES
AMINO ACIDS
ANIMALS
ARGININE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBONYLS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHLORIDES
CHLORINE COMPOUNDS
DATA
DECOMPOSITION
DIGESTIVE SYSTEM
DRUGS
ENDOCRINE GLANDS
ERYTHROCYTES
EXPERIMENTAL DATA
GLANDS
GLUCAGON
GLUCOSE
GLYCOLYSIS
HALIDES
HALOGEN COMPOUNDS
HEXOSES
HORMONES
HYPERGLYCEMIA
IN VITRO
IN VIVO
INFORMATION
INHALATION
INJECTION
INSULIN
INTAKE
INTRAPERITONEAL INJECTION
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
MONOSACCHARIDES
NICKEL CHLORIDES
NICKEL COMPOUNDS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
QUANTITY RATIO
RATS
RODENTS
SACCHARIDES
SOMATOSTATIN
STEROID HORMONES
SYMPATHOMIMETICS
TIME DEPENDENCE
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES