New aldehyde dehydrogenase isozymes in chemically induced liver tumors in the rat

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-152-39419· OSTI ID:7312228

Feinstein, R N; Fry, R J.M.; Cameron, E C; Peraino, C; Morris, H P

All liver tumors induced in rats by acetylaminofluorene (AAF) or dimethylaminoazobenzene (DAB), but only one out of 29 tumors induced by ethionine, exhibited new isozymes of aldehyde dehydrogenase. These new isozymes, which differed from those of normal liver with regard to activity, pI, stability, cellular distribution, and coenzyme specificity, were not found in fetal or regenerating rat liver, nor in spontaneous liver tumors of the mouse or mastomys, nor in several other tumors appearing in rats bearing AAF-induced liver tumors, nor in any of several transplanted Morris hepatomas. The activity of the new isozymes did not correlate with histological criteria of differentiation, and the new forms were sometimes detectable in the liver of AAF-fed rats in areas where no tumor was macroscopically or histologically visible.

• Research Organization: Argonne National Lab., IL
• OSTI ID: 7312228
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 152; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ACETYL RADICALS
ACYL RADICALS
ALDEHYDES
ALKYL RADICALS
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
AZINES
BARBITURATES
BENZENE
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CATALYSIS
COENZYMES
CONDENSED AROMATICS
DEHYDROGENASES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
ENZYMES
ETHIONINE
FLUORENE
GLANDS
HEPATOMAS
HETEROCYCLIC COMPOUNDS
HISTOLOGY
HYDROCARBONS
HYPNOTICS AND SEDATIVES
ISOENZYMES
LIPOTROPIC FACTORS
LIVER
MAMMALS
METABOLISM
METHYL RADICALS
MICE
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
PATHOGENESIS
PHENOBARBITAL
PYRIMIDINES
RADICALS
RATS
RODENTS
STABILITY
VERTEBRATES