Dose-response analysis of cadmium-induced tubular proteinuria. A study of urinary. beta. /sub 2/-microglobulin excretion among workers in a battery factory

Journal Article · Fri Apr 01 04:00:00 EST 1977 · Environ. Res.; (United States)

OSTI ID:7308351

Kjellstroem, T ^[1]; Evrin, P E; Rahnster, B

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1. Karolinska Inst. and National Environment Protection Board, Stockholm

The study covered 240 male and female workers exposed to cadmium oxide and nickel hydroxide dust in a Swedish battery factory. The control group comprised 87 unexposed males. Air samples from the plant showed the present exposure level to be about 50 ..mu..g Cd/m/sup 3/ air. Cadmium-induced effects were studied by measuring urinary ..beta../sub 2/-microglobulin excretion. Urinary ..beta../sub 2/-microglobulin concentration followed a log-normal distribution in the reference group with a geometric mean of 84 ..mu..g/liter (adjusted to a specific gravity of 1.023). In the group of 185 persons continuously exposed to cadmium dust in the work environment, the prevalence of increased urinary ..beta../sub 2/-microglobulin excretion increased with employment time. The prevalence was 19% for the workers with 6-12 years of exposure to about 50 ..mu..g Cd/m/sup 3/ as compared to 3% for those in the reference group. Smokers had about three times higher prevalence than nonsmokers.

• OSTI ID: 7308351
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 13:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ALBUMINURIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CADMIUM
COLLOIDS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DUSTS
ELECTRIC BATTERIES
ELECTROCHEMICAL CELLS
ELEMENTS
ENERGY STORAGE SYSTEMS
EUROPE
INDUSTRY
METALS
NICKEL
ORGANIC COMPOUNDS
PERSONNEL
POLLUTION
PROTEINS
RESIDUES
SCANDINAVIA
SMOKES
SOLS
SWEDEN
TOBACCO SMOKES
TRANSITION ELEMENTS
URINE
WASTES