Dose: response analysis of cadmium-induced tubular proteinuria

Journal Article · Fri Apr 01 04:00:00 EST 1977 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(77)90106-2· OSTI ID:5262718

Kjellstrom, T ^[1]; Evrin, P E; Rahnster, B

---

1. Karolinska Inst., Stockholm

The study covered 240 male and female workers exposed to cadmium oxide and nickel hydroxide dust in a Swedish battery factory. The control group comprised 87 unexposed males. Air samples from the plant showed the present exposure level to be about 50 ..mu..g Cd/m/sup 3/ air. Cadmium-induced effects were studied by measuring urinary ..beta../sub 2/-microglobulin excretion. Urinary ..beta../sub 2/-microglobulin concentration followed a log-normal distribution in the reference group with a geometric mean of 84 ..mu..g/liter (adjusted to a specific gravity of 1.023). In the group of 185 persons continuously exposed to cadmium dust in the work environment, the prevalence of increased urinary ..beta../sub 2/-microglobulin excretion increased with employment time. The prevalence was 19 percent for the workers with 6 to 12 years of exposure to about 50 ..mu..g Cd/m/sup 3/ as compared to 3 percent for those in the reference group. Smokers had about three times higher prevalence than nonsmokers.

• OSTI ID: 5262718
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 13:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CADMIUM COMPOUNDS
CADMIUM OXIDES
CHALCOGENIDES
CLEARANCE
COLLOIDS
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DUSTS
ELEMENTS
EUROPE
EXCRETION
HAZARDS
HEALTH HAZARDS
INDUSTRIAL WASTES
INHALATION
INTAKE
KIDNEYS
MAMMALS
MAN
METALS
NICKEL
OCCUPATIONAL DISEASES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
PROTEINS
RESIDUES
SCANDINAVIA
SMOKES
SOLS
SWEDEN
TOBACCO SMOKES
TRANSITION ELEMENTS
URINE
UROGENITAL SYSTEM DISEASES
VERTEBRATES
WASTES