Comparison between fecal cadmium and urinary. beta. /sub 2/-microglobulin, total protein, and cadmium among Japanese farmers

Journal Article · Thu Dec 01 04:00:00 EST 1977 · Environ. Res.; (United States)

OSTI ID:5165139

Kojima, S ^[1]; Haga, Y; Kurihara, T; Yamawaki, T; Kjellstroem, T

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1. Akita Prefecture Inst. of Public Health, Japan

A study was made of 156 farmers living in a cadmium-exposed area and 93 farmers in a reference area. All were between 50 and 69 years of age. Cadmium intake from food was estimated from daily fecal cadmium content, body burden from urinary cadmium concentration, and cadmium-induced renal effects from urinary ..beta../sub 2/-microglobulin (..beta../sub 2/-m) and total protein concentration. Average cadmium intake in the reference area was about 40 ..mu..g/day and in the exposed area about 150 ..mu..g/day. Average urinary cadmium excretion in the reference group was 2 ..mu..g/liter and in the exposed group 7.5 ..mu..g/liter. Average urinary ..beta../sub 2/-m concentration in the reference group was 86 ..mu..g/liter and we defined tubular proteinuria as a ..beta../sub 2/-m concentration higher than the average plus two standard deviations. With this definition the prevalence rate of tubular proteinuria was 3 percent in the reference group and 14 percent in the exposed group. Tubular proteinuria increased with age and with exposure duration. Increased total proteinuria was also more common in the exposed group but the prevalence rate ratio was 2.4 as compared to 4.4 for tubular proteinuria.

• OSTI ID: 5165139
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 14:3; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY BURDEN
BODY FLUIDS
CADMIUM
CLEARANCE
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EPIDEMIOLOGY
EXCRETION
FECES
FOOD
GLOBULINS
INTAKE
JAPAN
KIDNEYS
MAMMALS
MAN
METALS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
QUANTITY RATIO
URINE
VERTEBRATES
WASTES