Amino acid sequence of human platelet factor 4
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
Human platelet factor 4, a protein that binds heparin, has been purified to apparent homogeneity and the complete amino acid sequence of the protein has been determined. The 70-residue polypeptide chain contains no methionine, tryptophan, or phenylalanine, and contains only a single tyrosyl residue. The sequence analysis demonstrates a highly negatively charged amino-terminal region. The carboxyl-terminal region of the polypeptide is unusual in that it contains a repetitive clustering of positively charged and hydrophobic pairs of amino acids; preliminary evidence suggests that this domain may play a role in the binding of heparin.
- Research Organization:
- Univ. of Chicago
- OSTI ID:
- 7306926
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 74:6; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANIMALS
ANTICOAGULANTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
DISEASES
DRUGS
HEPARIN
MAMMALS
MAN
MOLECULAR STRUCTURE
MUCOPOLYSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POLYSACCHARIDES
PRIMATES
PROTEINS
SACCHARIDES
THROMBOSIS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANIMALS
ANTICOAGULANTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
DISEASES
DRUGS
HEPARIN
MAMMALS
MAN
MOLECULAR STRUCTURE
MUCOPOLYSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POLYSACCHARIDES
PRIMATES
PROTEINS
SACCHARIDES
THROMBOSIS
VERTEBRATES