Comparative pathology study of myocardial lesions and atherosclerosis in Japanese men living in Hiroshima, Japan and Honolulu, Hawaii

Journal Article · Wed Dec 31 23:00:00 EST 1975 · Lab. Invest.; (United States)

OSTI ID:7304957

Stemmermann, G N; Steer, A; Rhoads, G G; Lee, K; Hayashi, T; Nakashima, T; Keehn, R

Autopsies were conducted on Japanese men from 45 to 71 years of age in Hiroshima, Japan (191 patients) and in Honolulu, Hawaii (298 patients). They were performed according to a common protocol. In both locations the patients studied were representative of decedents from population-based cohorts with respect to age and cause of death. The degree of atherosclerosis in the coronary arteries and aorta, assessed according to the panel method, was found to be substantially more severe in men in Hawaii than in those in Japan. Areas of recent myocardial necrosis were 3.5 times more frequent in men in Honolulu than in those in Hiroshima. Large myocardial scars were 1.5 times more frequent in the men in Honolulu. It was characteristic of men in Honolulu that severe atherosclerosis and myocardial lesions appeared at younger ages than in those in Hiroshima. These data demonstrate that there is an increase in the frequency and severity of ischemic lesion in the myocardium of Japanese who have migrated to Hawaii and that this increase is the result of atherosclerosis of the extramural segments of the coronary arteries.

• Research Organization: National Heart and Lung Inst., Honolulu, Hawaii
• OSTI ID: 7304957
• Journal Information: Lab. Invest.; (United States), Journal Name: Lab. Invest.; (United States) Vol. 34:6; ISSN LAINA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ARTERIES
ARTERIOSCLEROSIS
ASIA
AUTOPSY
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
DIAGNOSTIC TECHNIQUES
DISEASES
HAWAII
HEART
HIROSHIMA
INJURIES
JAPAN
MUSCLES
MYOCARDIUM
NORTH AMERICA
ORGANS
PATHOLOGY
PATIENTS
USA
WESTERN REGION