Colony-stimulating activity in cultures of granulocyosis-inducing tumor

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-154-19610· OSTI ID:7300347

Burlington, H; Cronkite, E P; Laissue, J A; Reincke, U; Shadduck, R K

A transplantable mouse mammary carcinoma-producing granulocytosis in host mice has been established in cell cultures. Colony-stimulating activity (CSA) is released to the medium by both monolayers and suspension cultures over sustained periods. The CSA is heat labile and nondialyzable with an apparent molecular weight greater than 30,000. It is neutralized by antibody to colony-stimulating factor (CSF), suggesting that the material produced in tumor cell cultures is in fact CSF.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 7300347
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 154:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARCINOMAS
CELL CULTURES
DIALYSIS
DISEASES
DISPERSIONS
ENERGY
GLANDS
HEAT
LEUKOCYTES
MAMMALS
MAMMARY GLANDS
MICE
MOLECULAR WEIGHT
NEOPLASMS
ORGANS
POPULATIONS
RODENTS
SEPARATION PROCESSES
STIMULATION
SUSPENSIONS
TRANSPLANTS
VERTEBRATES