Colony-stimulating activity in cultures of granulocytosis-inducing tumor

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-154-19610· OSTI ID:5237430

Burlington, H ^[1]; Cronkite, E P; Laissue, J A; Reincke, U; Shadduck, R K

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1. Brookhaven National Lab., Upton, NY

A transplantable mouse mammary carcinoma-producing granulocytosis in host mice has been established in cell cultures. Colony-stimulating activity (CSA) is released to the medium by both monolayers and suspension cultures over sustained periods. The CSA is heat labile and nondialyzable with an apparent molecular weight > 30,000. It is neutralized by antibody to colony-stimulating factor (CSF), suggesting that the material produced in tumor cell cultures is in fact CSF.

• OSTI ID: 5237430
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 154; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOSYNTHESIS
BODY
CARBOHYDRATES
CARCINOMAS
CELL CULTURES
COLONY FORMATION
DISEASES
GLANDS
GLUCOPROTEINS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
SACCHARIDES
STIMULATION
SYNTHESIS
TUMOR CELLS
VERTEBRATES