Toxicology and metabolism of nickel compounds. Progress report, December 1, 1974--November 30, 1975. [97433ONE]

Technical Report · Fri Aug 15 04:00:00 EDT 1975

DOI:https://doi.org/10.2172/7299576· OSTI ID:7299576

Sunderman, Jr., F. W.

The toxicology and metabolism of nickel compounds (NiCl/sub 2/, Ni/sub 3/S/sub 2/, NiS, and Ni powder) were investigated in rats and hamsters. The new knowledge has included: demonstration that hyperglucagonemia is primarily responsible for the acute hyperglycemic effect of parenteral Ni(II) in rats; demonstration that parenteral injection of Ni(II) in rats produces acute nephropathy with proteinuria and amino aciduria, and with ultrastructural lesions of renal glomeruli and tubules; confirmation of the inhibitory effect of manganese upon the carcinogenicity of Ni/sub 3/S/sub 2/ after intramuscular injection in rats, and elucidation of the effects of manganese upon the rates of excretion of nickel, and upon the acute histological reactions produced by Ni/sub 3/S/sub 2/; discovery that the antidotal efficacy of triethylenetetramine (TETA) in acute Ni(II) poisoning in rats is substantially greater than that of other chelating agents, including ..cap alpha..-lipoic acid, diethyldithiocarbamate, d-penicillamine, and glycylglycyl-L-histidine-N-methylamide; observation that the acute renal toxicity of Ni(II) is suppressed by administration of TETA, but that the hyperglycemic and hyperglucagonemic responses to Ni(II) are not prevented by TETA; confirmation that marked erythrocytosis is induced in rats by a single intrarenal injection of Ni/sub 3/S/sub 2/, and elucidation of the time-response and dose-response relationships for the Ni-induced erythrocytosis. (auth)

• Research Organization: Connecticut Univ., Farmington (USA). School of Medicine
• OSTI ID: 7299576
• Report Number(s): COO-3140-34
• Country of Publication: United States
• Language: English

Related Subjects

550500* -- Metabolism
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ABUNDANCE
AMIDES
AMINES
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CARCINOGENESIS
CHELATING AGENTS
CLEARANCE
DISULFIDES
DRUGS
ELEMENTS
ERYTHROCYTES
EXCRETION
HAMSTERS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYPERGLYCEMIA
KIDNEYS
LIPOTROPIC FACTORS
MAMMALS
MANGANESE
METABOLISM
METALS
NICKEL COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGY
PENICILLAMINE
RADIOPROTECTIVE SUBSTANCES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
TETA
THIOCTIC ACID
THIOLS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES