Comparisons of antidotal efficacy of chelating drugs upon acute toxicity of Ni(II) in rats

Journal Article · Sat May 01 04:00:00 EDT 1976 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:7292190

Horak, E; Sunderman, Jr, F W; Sarkar, B

Six chelating drugs were administered to rats by im injection at equimolar dosages in order to compare their relative effectiveness in prevention of death after a single parenteral injection of NiCl/sub 2/. Triethylenetetramine and d-penicillamine were the most effective antidotes for acute Ni(II)-toxicity. In order of decreasing antidotal effectiveness, diglycyl-L-histidine-N-methylamide, sodium diethyldithiocarbamate and calcium disodium versenate significantly reduced the acute mortality of rats following ip injection of Ni(II). ..cap alpha..-Lipoic acid was not effective as an antidote for acute Ni(II)-toxicity.

• Research Organization: Univ. of Connecticut, Farmington
• OSTI ID: 7292190
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 14:1; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
ANIMALS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
COMPARATIVE EVALUATIONS
DISULFIDES
DRUGS
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LIPOTROPIC FACTORS
MAMMALS
MORTALITY
NICKEL CHLORIDES
NICKEL COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PENICILLAMINE
RADIOPROTECTIVE SUBSTANCES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
TETA
THIOCTIC ACID
THIOLS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES