Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator. [Fluocinolone acetonide, fluocinonide, fluclorolone acetonide]

Journal Article · Sun May 01 04:00:00 EDT 1977 · Cancer Res.; (United States)

OSTI ID:7297947

Viaje, A; Slaga, T J; Wigler, M; Weinstein, I B

The antiinflammatory steroids fluocinolone acetonide, fluocinonide, and fluclorolone acetonide were found to be very effective inhibitory agents of mouse skin tumor promotion. These steroids also drastically inhibited epidermal DNA synthesis and epidermal cellular proliferation induced by a phorbal ester tumor promoter. In addition, these compounds were potent inhibitors of plasminogen activator production in tumor cell cultures. The clinically used nonsteroidal antiinflammatory agents oxyphenbutazone, indomethacin, and Seclazone also inhibited tumor promotion but were much less effective. Although these agents are useful against inflammatory disorders in general when given p.o., in our studies they had little effect on inflammation and epidermal cellular proliferation induced by a phorbol ester tumor promoter when given topically. The aforementioned nonsteroidal antiinflammatory agents also had little effect on epidermal DNA synthesis. Oxyphenbutazone and indomethacin were less potent inhibitors of plasminogen activator production in tumor cells than were the antiinflammatory steroids, and Seclazone produced a negligible inhibition. There is, therefore, a general correlation in the potencies of a series of steroidal antiinflammatory agents for inhibition of tumor promotion and their ability to inhibit plasminogen activator production by tumor cell cultures and epidermal DNA synthesis.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 7297947
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 37; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARCINOGENESIS
CELL PROLIFERATION
DISEASES
DNA
DRUGS
INHIBITION
MAMMALS
MICE
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
SKIN
STEROIDS
SYNTHESIS
VERTEBRATES