Antiinflammatory drug effects on ultraviolet light-induced epidermal ornithine decarboxylase and DNA synthesis

Journal Article · Sun Jun 01 04:00:00 EDT 1980 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12544563· OSTI ID:6537806

Lowe, N J; Breeding, J

Epidermal ornithine decarboxylase activity is greatly elevated in response to tumor promoting agents and ultraviolet light. The purpose of this paper is to report modification of ultraviolet-induced epidermal ornithine decarboxylase activity by antiinflammatory agents. Topical triamoinolone acetonide and indomethacin were found to significantly inhibit the UV-B induction of epidermal ornithine decarboxylase in hairless mice when applied following ultraviolet light irradiation. The corticosteroid also showed inhibition of ultraviolet light increased epidermal DNA synthesis. Indomethacin failed to show any inhibition of DNA synthesis.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 6537806
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 74:6; ISSN JIDEA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
CARBOXYLIC ACIDS
CORTICOSTEROIDS
DECARBOXYLASES
DNA REPLICATION
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
EPIDERMIS
EPITHELIUM
FAR ULTRAVIOLET RADIATION
HORMONES
HYDROXY COMPOUNDS
KETONES
LYASES
MAMMALS
MICE
NUCLEIC ACID REPLICATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
ORNITHINE
PREGNANES
PROMOTERS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SKIN
STEROID HORMONES
STEROIDS
TISSUES
TUMOR PROMOTERS
ULTRAVIOLET RADIATION
VERTEBRATES